A family has been shattered after a horrific crash in the city's west end.
It happened just before 3am when a GMC envoy was travelling the wrong way on the eastbound QEW ramp to the northbound 427, hitting a Dodge Caravan head-on.
The OPP say a 49-year-old man and a 16-year-old girl are dead, while a 50-year-old woman is in hospital with life-threatening injuries.
The driver of the GMC Envoy, a 19-year-old man, has been arrested for impaired and is in hospital.
Police say the ramp will remain closed for some time while police investigate.